• It’s a specific pattern of hippocampal neuron cell loss due to certain brain injuries
  • Associated hippocampal atrophy and gliosis is common
  • Closely related to temporal lobe epilepsy due to the damage ( a focal epilepsy in which the seizure initiation point can be identified within the temporal lobe of the brain)
  • 70% of temporal lobe epilepsy patients have some degree of mesial temporal sclerosis
The brain injuries that gives rise to this condition are :
– Traumatic brain damage
– Infection
– Lack of oxygen to the brain
– Uncontrolled/ additional  seizures can worsen the sclerosis


* Partial (focal epilepsy)

* Strange sensations

* Changes in behaviour or emotions

* Muscle spasms or comvulsions

The seizures usually are localized in the brain, but they may spread to become generalized seizures, which involve the entire brain and may cause a sudden loss of awareness or consciousness.


MRI scan commonly displays increased T2 signal and hippocampal atrophy


  • Temporal lobectomy to get rid of the seizures
  • The best outcome are in patients with unilateral mesial temporal sclerosis


It should be noted that the removal of sclerotic tissue likely will cause just a few neurological impairments because the tissue already is damaged. In addition, because seizures can cause mesial temporal sclerosis to spread, it is important to address them before they cause more neurological damage.










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